METHYL 4-BROMOCROTONATE

1. STRUCTURE

2. PRODUCT NAME & DETAILS
Product Name	Methyl 4-bromocrotonate
Product Code	005409
CAS No	1117-71-1
HS Code	2916.39.90
Molecular Formula	C5H7BrO2
Molecular Wt.	179.02

3. REGULATORY INFORMATION
Chemical name	Common names and synonyms	CAS number	EC number
Methyl 4-bromocrotonate	Methyl 4-bromocrotonate	1117-71-1	214-251-0
European Inventory of Existing Commercial Chemical Substances (EINECS)			Listed
EC Inventory			Listed
United States Toxic Substances Control Act (TSCA) Inventory			Listed
China Catalog of Hazardous chemicals 2015			Not Listed
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)			Listed
Korea Existing Chemicals List (KECL)			Not Listed
Canadian Domestic Substance List (DSL)			Not Listed
Canadian Non-Domestic Substance List (NDSL)			Listed
Japanese Existing and New Chemical Substances Inventory(ENCS)			Not Listed

4. SPECIFICATION
Physical Appearance	Pale Yellow To Orange Liquid
Miscibility	Miscible With Methanol
Moisture Content (KF)	NMT 0.50%
Purity (GC)	NLT 85.0%
CIS Isomer (GC)	NMT 2.00%

5. APPLICATION

It is a useful synthetic intermediate.

It was used in the synthesis of irreversible inhibitors of EGFR and HER-2 tyrosine kinases with enhanced antitumor activities.

An antitumor drug Dacomitinib was synthesized using Methyl-4-bromocrotonate.
It is a inhibitor of EGFR (epidermal growth factor receptor).

6. HAZARD CLASSIFICATION

Hazardous substance. (UN No. 1760)

Irritant

Corrosive

7. ANNUAL CAPACITY

6 MT.

8. STORAGE CONDITION

Store in closed container at 25-30°C. Avoid direct sun light.

9. PACKING DETAILS

50kg GI Drum with Screw Lid.

10. SHELF LIFE

4 months.

Disclaimer
Typical properties should not be considered as specification. Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer. Products will not be supplied to countries where they could be in conflict with existing patents. Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.

Disclaimer

Typical properties should not be considered as specification.
Product covered by valid patents are not offered or supplied for commercial use. The Patent position should be verified by the customer.
Products will not be supplied to countries where they could be in conflict with existing patents.
Products currently covered by valid US patents are offered for R&D use in accordance with 35 USC 271 (e) (I) Above information is given in good faith and without warrenty.

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